ROXAS is not stand-alone, but depends on the commercial software Image-Pro Plus v6.1-7 (Media Cybernetics). There is currently no alternative to this dependency.

Image file format - JPG
- JPEG2000 (JP2)
- Color and grey scale images supported
Image file size Max. 32,768 pixels in any dimension
Software - Image-Pro Plus (Media Cybernetics) v6.1-v7 (not 6.0!)
- MS Excel 2003 through 2019
Operating system - Vista / 7
- Windows 10, however, you might have to run Image-Pro Plus in the compatibility mode!
- Windows 8 / 8.1: proper functioning is not guaranteed!
Hardware - ≥8 GB RAM for images <25 megapixels (e.g. 5000 × 5000 pixels)
- ≥12 GB RAM & powerful graphics card for images >25 megapixels
- Monitor size: 800 × 1200 or larger (the larger, the better! But 4K resolution not recommended since single-pixel lines appear very small)
- Optional: graphic tablet for manual editing (instead of mouse)

There are likely also undiscovered bugs that show in specific situations. You may help to improve ROXAS by reporting them to the developer (provide screenshot of the error message together with all files associated with erroneous analysis).